Entsyymi cysteiinidioxygenaasi CDO1 (5q22.3) on primäärinen cysteiiniä metaboloiva entsyymi ja tuote on kysteiinisulfiinihappoa CSAD.
(Tämä CDO1 entsyymi on säätelyllinen alkukohta sulfaatin muodostuksessa. Sulfaattia tarvitaan detoksikaatiojärjestelmään ja erilaisten rikkiä sisältävien kehomolekyylien luomiseen. Sulfotransferaaseja ja arylsulfataasientsyymejä taas avustaa kofaktorina k-vitamiini ja B6 vitamiini)
CDO1 Cystein dioxygenase 1https://www.ncbi.nlm.nih.gov/gene/1036
- Official Symbol CDO1
- Official Full Name cysteine dioxygenase type 1provided by HGNC
- Also known as CDO-I
- Expression Biased expression in liver (RPKM 94.6), fat (RPKM 66.8) and 8 other tissues See more
- Orthologs mouse all
- Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma. Nakamoto S, et al. PLoS One, 2018. PMID 30325974, Free PMC Article
- Epigenetic Status of CDO1 Gene May Reflect Chemosensitivity in Colon Cancer with Postoperative Adjuvant Chemotherapy. Yokoi K, et al. Ann Surg Oncol, 2019 Feb. PMID 30311169
- Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer. Kojima K, et al. PLoS One, 2018. PMID 29746493, Free PMC Article
- Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. Igarashi K, et al. PLoS One, 2017. PMID 29161283, Free PMC Article
- The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma. Kojima K, et al. Dis Esophagus, 2017 Mar 1. PMID 28184414
GeneRIFs: Gene References Into Functions
- High expression of CDO1 gene increased chemoresistance in Colon Cancer.
- In the present study, we compared the 2 potential epigenetic prognostic markers of CDO1 hypermethylation and HOPX hypermethylation using the same breast cancer samples, and the final focus was given on CDO1 hypermethylation
- CDO1 hypermethylation, preoperative serum CA19-9 and perineural invasion were independent prognostic factors in primary extrahepatic cholangiocarcinoma
- High CDO1 methylation is associated with colorectal cancer progression.
- Promoter NA methylation of CDO1 was demonstrated for the first time to be a cancer-associated methylation in primary gallbladder cancer(GBC), and it has the potential to be a prognostic biomarker of GBC for high-risk patients with stage II GBC.
- CDO1 methylation could be a potent prognostic predictor in primary esophageal squamous cell carcinoma and have great potential as a prognostic factor to guide the treatment of patients who need adjuvant chemotherapy.
- High methylation of CDO1 gene is responsible of the development of the esophageal adenocarcinoma.
- CDO1 promoter methylation is involved in gene regulation and is a potential prognostic biomarker for BCR-free survival in prostate cancer (PC) patients following radical prostatectomy. Further studies are needed to validate CDO1 methylation assays and to evaluate the clinical utility of CDO1 methylation for the management of PCa
- methylation of the CDO1 gene promoter could be strong prognostic indicator in primary BC without preoperative treatment.
- CDO1 promoter methylation may not substitute common prognostic makers to predict ccRCC survival, but offers additional, relevant prognostic information, indicating that it might be a novel molecular marker to determine ccRCC prognosis
The protein CDO1 https://www.ncbi.nlm.nih.gov/protein/NP_001310494.1
LOCUS NP_001310494 219 aa linear PRI 01-JUN-2019 DEFINITION cysteine dioxygenase type 1 isoform 1 [Homo sapiens]. ACCESSION NP_001310494 VERSION NP_001310494.1 DBSOURCE REFSEQ: accession NM_001323565.2 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 219) AUTHORS Tanaka Y, Kosaka Y, Waraya M, Yokota K, Harada H, Kaida T, Kikuchi M, Minatani N, Nishimiya H, Katoh H, Sengoku N, Watanabe M and Yamashita K. TITLE Differential Prognostic Relevance of Promoter DNA Methylation of CDO1 and HOPX in Primary Breast Cancer JOURNAL Anticancer Res. 39 (5), 2289-2298 (2019) PUBMED 31092420 REMARK GeneRIF: In the present study, we compared the 2 potential epigenetic prognostic markers of CDO1 hypermethylation and HOPX hypermethylation using the same breast cancer samples, and the final focus was given on CDO1 hypermethylation REFERENCE 2 (residues 1 to 219) AUTHORS Yokoi K, Harada H, Yokota K, Ishii S, Tanaka T, Nishizawa N, Shimazu M, Kojo K, Miura H, Yamanashi T, Sato T, Nakamura T, Watanabe M and Yamashita K. TITLE Epigenetic Status of CDO1 Gene May Reflect Chemosensitivity in Colon Cancer with Postoperative Adjuvant Chemotherapy JOURNAL Ann. Surg. Oncol. 26 (2), 406-414 (2019) PUBMED 30311169 REMARK GeneRIF: High expression of CDO1 gene increased chemoresistance in Colon Cancer. REFERENCE 3 (residues 1 to 219) AUTHORS Nakamoto S, Kumamoto Y, Igarashi K, Fujiyama Y, Nishizawa N, Ei S, Tajima H, Kaizu T, Watanabe M and Yamashita K. TITLE Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma JOURNAL PLoS ONE 13 (10), e0205864 (2018) PUBMED 30325974 REMARK GeneRIF: CDO1 hypermethylation, preoperative serum CA19-9 and perineural invasion were independent prognostic factors in primary extrahepatic cholangiocarcinoma Publication Status: Online-Only REFERENCE 4 (residues 1 to 219) AUTHORS Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M and Yamashita K. TITLE Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer JOURNAL PLoS ONE 13 (5), e0194785 (2018) PUBMED 29746493 REMARK GeneRIF: High CDO1 methylation is associated with colorectal cancer progression. Publication Status: Online-Only REFERENCE 5 (residues 1 to 219) AUTHORS Igarashi K, Yamashita K, Katoh H, Kojima K, Ooizumi Y, Nishizawa N, Nishiyama R, Kawamata H, Tajima H, Kaizu T, Kumamoto Y and Watanabe M. TITLE Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease JOURNAL PLoS ONE 12 (11), e0188178 (2017) PUBMED 29161283 REMARK GeneRIF: Promoter NA methylation of CDO1 was demonstrated for the first time to be a cancer-associated methylation in primary gallbladder cancer(GBC), and it has the potential to be a prognostic biomarker of GBC for high-risk patients with stage II GBC. Publication Status: Online-Only REFERENCE 6 (residues 1 to 219) AUTHORS Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J and Ducar M. TITLE Creation of genome-wide protein expression libraries using random activation of gene expression JOURNAL Nat. Biotechnol. 19 (5), 440-445 (2001) PUBMED 11329013 REFERENCE 7 (residues 1 to 219) AUTHORS Qusti S, Parsons RB, Abouglila KD, Waring RH, Williams AC and Ramsden DB. TITLE Development of an in vitro model for cysteine dioxygenase expression in the brain JOURNAL Cell Biol. Toxicol. 16 (4), 243-255 (2000) PUBMED 11101006 The development of an in vitro model for cysteine dioxygenase (CDO) expression in the brain would provide a useful model for determining the mechanisms for the regulation of CDO expression that does not involve the use of animals. Here we demonstrate the screening and characterization of a cell line that expresses CDO, the primary metabolizing enzyme of cysteine and the regulatory point of sulfate production. A panel of four commercially available tumor-derived human brain cell lines, each representing one major class of brain cell, were screened using western blotting and activity assay for cysteine dioxygenase expression. One cell line, TE 671 (human medulloblastoma) was found to express both a protein of approximately 70 kDa and CDO activity. Nuclease protection assay (NPA) of mRNA isolated from TE 671 showed the expression of a CDO mRNA. Reverse transcription-polymerase chain reaction of this mRNA and sequencing of the cDNA obtained showed that this was indeed CDO. Treatment of TE 671 cells with cysteine resulted in the upregulation of CDO mRNA, whereas treatment with tumor necrosis factor alpha resulted in the downregulation of CDO mRNA, as evidenced using NPA. The characterization of an in vitro model for CDO expression provides a useful tool for the investigation of this important enzyme, which may have an etiological role in the pathogenesis of Parkinson's disease. REFERENCE 8 (residues 1 to 219) AUTHORS Ramsden DB, Kapadi A, Fitch NJ, Farmer MJ, Bennett P and Williams AC. TITLE Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene JOURNAL MP, Mol. Pathol. 50 (5), 269-271 (1997) PUBMED 9497919 REFERENCE 9 (residues 1 to 219) AUTHORS Jeremiah S, McCann KP, Williams AC, Ramsden DB, Pilz AJ, Fox MF and Povey S. TITLE Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase JOURNAL Ann. Hum. Genet. 60 (1), 29-33 (1996) PUBMED 8835096 REFERENCE 10 (residues 1 to 219) AUTHORS McCann KP, Akbari MT, Williams AC and Ramsden DB. TITLE Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA JOURNAL Biochim. Biophys. Acta 1209 (1), 107-110 (1994) PUBMED 7524679 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026449.6, DA849625.1, AK130357.1 and BC024241.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189664.60540.1, SRR1803613.237389.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146, SAMEA2467147 [ECO:0000348] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..219 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="5" /map="5q22.3" Protein 1..219 /product="cysteine dioxygenase type 1 isoform 1" /EC_number="1.13.11.20" /note="cysteine dioxygenase, type I" /calculated_mol_wt=24700 CDS 1..219 /gene="CDO1" /gene_synonym="CDO-I" /coded_by="NM_001323565.2:263..922" /note="isoform 1 is encoded by transcript variant 1" /db_xref="GeneID:1036" /db_xref="HGNC:HGNC:1795" /db_xref="MIM:603943" ORIGIN 1 meqtevlkpr tladlirilh qlfagdevnv eevqaimeay esdptewamy akfdqysrgr 61 glqfvvgggs gggwlwytrn lvdqgngkfn lmilcwgegh gssihdhtns hcflkmlqgn 121 lketlfawpd kksnemvkks ervlrenqca yindsiglhr venishtepa vslhlysppf 181 dtchafdqrt ghknkvtmtf hskfgirtpn atsgslenn //
- Seuraaksi CSAD- molekyylistä cysteinsulphinic acid , kysteiinisulfiinihappo.
