Tämän viitteen löysin Fibromyalgiatutkimuksista, joita Riksstämman 2010 esitti.
Altered amino acid homeostasis in subjects affected by fibromyalgia.
Bazzichi L1, Palego L, Giannaccini G, Rossi A, De Feo F, Giacomelli C, Betti L, Giusti L, Mascia G, Bombardieri S, Lucacchini A.
- 1
- Department of Internal Medicine, Division of Rheumatology, University of Pisa, Via Roma 67, 56126 Pisa, Italy. l.bazzichi@int.med.unipi.it
Abstract
OBJECTIVES:
To evaluate plasma amino acid (AA) concentrations in patients affected by fibromyalgia (FM) and to study the relationships between their levels and FM clinical parameters.DESIGN AND METHODS:
20 AAs were assessed in 34 FM patients and in 18 healthy volunteers by means of a modified version of the Waters picotag method.RESULTS:
Significant lower plasma taurine, alanine, tyrosine (Tyr), valine, methionine, phenylalanine and threonine concentrations, and the sum of essential AAs were observed in FM patients vs healthy controls (P<0 .05="" aas="" and="" b="" brain="" caa="" competing="" fm="" for="" in="" of="" ratio="" reduced="" significantly="" sum="" the="" tryptophan="" tyr="" uptake="" were="" with="">A significant correlation was found between FM clinical parameters and certain AAs.CONCLUSIONS:
Our results suggest probable defects of gut malabsorption of certain AAs in FM patients. Moreover, given the reduced Tyr CAA' ratio in FM patients, a possible impairment of the cathecolaminergic system in the FM syndrome may be suggested.- PMID:
- 19281806
- DOI:
- 10.1016/j.clinbiochem.2009.02.025
- [Indexed for MEDLINE]
