https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT1A&keywords=metallothionein
*MT1A
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This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]
GeneCards Summary for MT1A Gene
MT1A (Metallothionein 1A) is a Protein Coding gene. Diseases associated with MT1A include Menkes Disease and Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT2A.
UniProtKB/Swiss-Prot Summary for MT1A Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. ( MT1A_HUMAN,P04731 )
* MT1B
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The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]
GeneCards Summary for MT1B Gene
MT1B (Metallothionein 1B) is a Protein Coding gene. Diseases associated with MT1B include Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT1X.
UniProtKB/Swiss-Prot Summary for MT1B Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. ( MT1B_HUMAN,P07438 )
* MTC1P, pseudogene
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT1CP&keywords=MT1F
Molecular function for MT1CP Gene according to GENATLAS
- Biochemistry:
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- metallothionein 1CP cluster MT1CP
* MT1DP pseudogene
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT1DP&keywords=MT1F
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Predicted to enable metal ion binding activity. Predicted to be involved in cellular response to metal ion; cellular zinc ion homeostasis; and detoxification of copper ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1DP Gene
MT1DP (Metallothionein 1D, Pseudogene) is a Pseudogene. Diseases associated with MT1DP include Gastric Cancer and Hepatocellular Carcinoma.
UniProtKB/Swiss-Prot Summary for MT1DP Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals. ( MT1DP_HUMAN,A1L3X4 )
* MT1E
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Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1E Gene
MT1E (Metallothionein 1E) is a Protein Coding gene. Diseases associated with MT1E include Frontometaphyseal Dysplasia 1 and Bladder Cancer. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT2A.
* MT1F
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Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1F Gene
MT1F (Metallothionein 1F) is a Protein Coding gene.
Diseases associated with MT1F include Deficiency Anemia.
Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli.
An important paralog of this gene is MT1G.
*MT1G
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Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1G Gene
MT1G (Metallothionein 1G) is a Protein Coding gene. Diseases associated with MT1G include Hepatocellular Carcinoma and Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT2A.
* MT1H
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Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1H Gene
MT1H (Metallothionein 1H) is a Protein Coding gene. Diseases associated with MT1H include Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT1HL1.
*MT1L
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Predicted to enable zinc ion binding activity. Involved in cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1L Gene
MT1L (Metallothionein 1L, Pseudogene) is a Pseudogene. Among its related pathways are Metal ion SLC transporters and Copper homeostasis.
UniProtKB/Swiss-Prot Summary for MT1L Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. ( MT1L_HUMAN,Q93083 )
* MT1M ( alias * MT1K)
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This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
GeneCards Summary for MT1M Gene
MT1M (Metallothionein 1M) is a Protein Coding gene. Diseases associated with MT1M include Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT1B.
UniProtKB/Swiss-Prot Summary for MT1M Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. ( MT1M_HUMAN,Q8N339 )
*MT1X
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Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in cellular response to cadmium ion; cellular response to erythropoietin; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for MT1X Gene
MT1X (Metallothionein 1X) is a Protein Coding gene. Diseases associated with MT1X include Deficiency Anemia. Among its related pathways are Metal ion SLC transporters and Cellular responses to stimuli. An important paralog of this gene is MT2A.
UniProtKB/Swiss-Prot Summary for MT1X Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525). ( MT1X_HUMAN,P80297 )
*MT2
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT2A&keywords=MT2
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This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions, altering the intracellular concentration of heavy metals in the cell. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. The encoded protein interacts with the protein encoded by the homeobox containing 1 gene in some cell types, controlling intracellular zinc levels, affecting apoptotic and autophagy pathways. Some polymorphisms in this gene are associated with an increased risk of cancer. [provided by RefSeq, Sep 2017]
GeneCards Summary for MT2A Gene
MT2A (Metallothionein 2A) is a Protein Coding gene. Diseases associated with MT2A include Scrapie and Osteogenesis Imperfecta, Type X. Among its related pathways are Metal ion SLC transporters and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include obsolete drug binding. An important paralog of this gene is MT1G.
UniProtKB/Swiss-Prot Summary for MT2A Gene
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. ( MT2_HUMAN,P02795 )
* MT3
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT3&keywords=MT3
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This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]
*MT4
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MT4&keywords=MT3
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Predicted to enable metal ion binding activity. Predicted to be involved in cellular response to metal ion; cellular zinc ion homeostasis; and detoxification of copper ion. Predicted to act upstream of or within cellular metal ion homeostasis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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