Acta Hepatogastroenterol (Stuttg). 1977 Feb;24(1):15-9.
Bile salts secretion in cirrhosis. Correia JP, Areias E, Meneses L, Tiago E.
Tiivistelmä, Abstract
Tässä tutkimuksessa katsottiin 10 terveeltä ja 16 kirroottiselta ( alkoholi syynä kirroosiin) henkilöltä sappihappojen eritys 60 min. sekretiini-injektion jålkeen. Mitattiin totaalisappihapot eräällä entsymaattisella menetelmällä ja yksittäiset sappihapot erotettiin kromatografisesti. pitoisuus oli suurempi terveillä, vaikka ero ei ollut merkitsevää luokkaa. Kuitenkin ensimmäisten 20 minuutin aikana useimmilla terveillä oli erittyvien sappihappojen pitoisuus suurempi kuin kirroottisilla. molemmissa ryhmissä oli tri-OH happojen suhde di-OH- happoihin samanlainen. Glysiiniin tai tauriiniin konjugoituneitten sappisuolojen välinen suhde oli terveillä suurempi ja vapaitten sappisuolojen suhde konjugoituneisiin sappisuoloihin oli kirroottisilla suurempi. Mitä matalampi oli totaalisappihappojen pitoisuus heti Sekretiinin jälkeen, sitä suurempi osuus oli tauriinikonjugaatteja ja vapaita sappisuoloja, mitkä saattavat olla tärkeitä tekijöitä ruoansulatus- ja absorbotumisvaikeuksissa, joita alkoholikirroosissa esiintyy.
The bile salts secretion was studied in ten normal subjects and sixteen patients with alcoholic cirrhosis, in a basal period and during 60 minutes after Secretin injection. Total bile salts were measured by a modification of the enzymatic method of Iwata and Yamasaki and the individual bile salts were separated by silica gel thin-layer chromatography. During the 60 minutes after Secretin the mean concentration was 2.88 +/- 2.58 muM/ml in normals and 1.96 +/- 1.25 muM/ml in cirrhotics. The difference is not significant. During the first 20 minutes however the concentration was higher than 3 muM/ml in 8 out of 10 normals and lower than 2 muM/ml in 10 out 16 cirrhotics. The ratios of tri-to dihydroxy bile salts was similar in both groups. The ratios between bile salts conjugated with glycine and with taurine was higher in normals, and the ratio between free to conjugated bile salts was higher in cirrhotics. The lower concentration of total bile salts immediatly after Secretin, the higher proportion of taurin conjugates and of free bile salts could be important factors in the difficulties of fact digestion and absorption frequently found in patients with alcoholic cirrhosis.
The bile salts secretion was studied in ten normal subjects and sixteen patients with alcoholic cirrhosis, in a basal period and during 60 minutes after Secretin injection. Total bile salts were measured by a modification of the enzymatic method of Iwata and Yamasaki and the individual bile salts were separated by silica gel thin-layer chromatography. During the 60 minutes after Secretin the mean concentration was 2.88 +/- 2.58 muM/ml in normals and 1.96 +/- 1.25 muM/ml in cirrhotics. The difference is not significant. During the first 20 minutes however the concentration was higher than 3 muM/ml in 8 out of 10 normals and lower than 2 muM/ml in 10 out 16 cirrhotics. The ratios of tri-to dihydroxy bile salts was similar in both groups. The ratios between bile salts conjugated with glycine and with taurine was higher in normals, and the ratio between free to conjugated bile salts was higher in cirrhotics. The lower concentration of total bile salts immediatly after Secretin, the higher proportion of taurin conjugates and of free bile salts could be important factors in the difficulties of fact digestion and absorption frequently found in patients with alcoholic cirrhosis.
- PMID:
- 848242
- [PubMed - indexed for MEDLINE]
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