Istukan välittämä tauriini ja sikiön neuronaalinen kehitys

https://www.ncbi.nlm.nih.gov/pubmed/28849440
Abstract

Adv Exp Med Biol. 2017;975 Pt 1:17-25. doi: 10.1007/978-94-024-1079-2_2.

Functions of Maternally-Derived Taurine in Fetal and Neonatal Brain Development.

Tochitani S^1,2,3.

 

Abstract

Taurine (2-aminoethanesulfonic acid) is a sulfur-containing organic acid, which has various physiological functions, including membrane stabilization, cell-volume regulation, mitochondrial protein translocation, anti-oxidative activity, neuroprotection against neurotoxicity and modulation of intracellular calcium levels. Taurine also activates GABA_A receptors and glycine receptors. Mammalian fetuses and infants are dependent on taurine delivered from their mothers via either the placenta or their mother's milk. Taurine is a molecule that links mother-fetus or mother-infant bonding.This review describes the functions of taurine and the mechanisms of action of taurine in fetal and brain development. Taurine is involved in regulating the proliferation of neural progenitors, migration of newly-generated neurons, and the synapse formation of neurons after migration during fetal and neonatal development. In this review, we also discuss the environmental factors that might influence the functional roles of taurine in neural development.

KEYWORDS:
Brain development; Environmental factor; Mother-infant relationship; Obesity; Obstetric complication; Placental transfer; Taurine

PMID:

28849440

DOI:

10.1007/978-94-024-1079-2_2

[Indexed for MEDLINE]