Sulfaatinkuljetusgeenit : sulfaattipermeaasi perhe DRA (SLC26A3) ja SUT-1

 Ihmisen sulfaattinkuljettajageeneistä 1)  DRA ja  2) SUT-1

DRA mainitaan pubMed lähteessä lähinnä kloridin ja bikarbonaatin vaihtajana. Onko tällä jotain tekemistä sulfaatin kanssa?

SLC26A3, DRA, CLD (7q22.3-31.1)
https://www.ncbi.nlm.nih.gov/gene/1811

Also known as

CLD; DRA

Summary

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]

Expression

Biased expression in colon (RPKM 709.1), duodenum (RPKM 299.0) and 1 other tissue See more

Orthologs mouse all

Preferred Names

chloride anion exchanger

Names down-regulated in adenoma protein solute carrier family 26 (anion exchanger), member 3

 

Features

1. NM_000111.2 → NP_000102.1  chloride anion exchanger
   See identical proteins and their annotated locations for NP_000102.1
   
   

   Conserved Domains (3) summary

   cd07042
   Location:526 → 712

   STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

   COG0636
   Location:376 → 432

   AtpE; FoF1-type ATP synthase, membrane subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]

   pfam00916
   Location:73 → 475

   Sulfate_transp; Sulfate permease family

 Features: ( assosioituminen colon tauteihin ja kloridiripuliin)

https://www.ncbi.nlm.nih.gov/protein/NP_000102.1

 

 Protein         1..764
                     /product="chloride anion exchanger"
                     /note="down-regulated in adenoma protein; solute carrier
                     family 26 (anion exchanger), member 3"
                     /calculated_mol_wt=84374
     Region          73..475
                     /region_name="Sulfate_transp"
                     /note="Sulfate permease family; pfam00916"
                     /db_xref="CDD:279284"

 Region          376..432
                     /region_name="AtpE"
                     /note="FoF1-type ATP synthase, membrane subunit
                     c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy
                     production and conversion]; COG0636" 

   Region          526..712
                     /region_name="STAS_SulP_like_sulfate_transporter"
                     /note="Sulphate Transporter and Anti-Sigma factor
                     antagonist domain of SulP-like sulfate transporters, plays
                     a role in the function and regulation of the transport
                     activity, proposed general NTP binding function; cd07042" 

GeneRIF: TNFalpha may act reciprocally with DRA, leading to the
            development of intestinal inflammation.