(1) Cysteiiniaminohaposta kohti tauriinin tai sulfaatin muodostusta cys-dioxygenaasilla CDO1, joka tekee cysteiinisulfiinihappoa.

 Entsyymi cysteiinidioxygenaasi CDO1  (5q22.3)  on primäärinen cysteiiniä metaboloiva entsyymi ja tuote on  kysteiinisulfiinihappoa CSAD.

   (Tämä  CDO1 entsyymi on säätelyllinen alkukohta  sulfaatin  muodostuksessa. Sulfaattia tarvitaan detoksikaatiojärjestelmään ja  erilaisten rikkiä sisältävien kehomolekyylien luomiseen. Sulfotransferaaseja  ja arylsulfataasientsyymejä taas  avustaa kofaktorina k-vitamiini ja B6 vitamiini)

 CDO1  Cystein dioxygenase 1
https://www.ncbi.nlm.nih.gov/gene/1036

Official Symbol CDO1

Official Full Name cysteine dioxygenase type 1provided by HGNC

Also known as CDO-I

Expression Biased expression in liver (RPKM 94.6), fat (RPKM 66.8) and 8 other tissues See more

Orthologs mouse all

Related articles in PubMed

1. Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma. Nakamoto S, et al. PLoS One, 2018. PMID 30325974, Free PMC Article
2. Epigenetic Status of CDO1 Gene May Reflect Chemosensitivity in Colon Cancer with Postoperative Adjuvant Chemotherapy. Yokoi K, et al. Ann Surg Oncol, 2019 Feb. PMID 30311169
3. Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer. Kojima K, et al. PLoS One, 2018. PMID 29746493, Free PMC Article
4. Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. Igarashi K, et al. PLoS One, 2017. PMID 29161283, Free PMC Article
5. The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma. Kojima K, et al. Dis Esophagus, 2017 Mar 1. PMID 28184414

See all (43) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. High expression of CDO1 gene increased chemoresistance in Colon Cancer.
2. In the present study, we compared the 2 potential epigenetic prognostic markers of CDO1 hypermethylation and HOPX hypermethylation using the same breast cancer samples, and the final focus was given on CDO1 hypermethylation
3. CDO1 hypermethylation, preoperative serum CA19-9 and perineural invasion were independent prognostic factors in primary extrahepatic cholangiocarcinoma
4. High CDO1 methylation is associated with colorectal cancer progression.
5. Promoter NA methylation of CDO1 was demonstrated for the first time to be a cancer-associated methylation in primary gallbladder cancer(GBC), and it has the potential to be a prognostic biomarker of GBC for high-risk patients with stage II GBC.
6. CDO1 methylation could be a potent prognostic predictor in primary esophageal squamous cell carcinoma and have great potential as a prognostic factor to guide the treatment of patients who need adjuvant chemotherapy.
7. High methylation of CDO1 gene is responsible of the development of the esophageal adenocarcinoma.
8. CDO1 promoter methylation is involved in gene regulation and is a potential prognostic biomarker for BCR-free survival in prostate cancer (PC) patients following radical prostatectomy. Further studies are needed to validate CDO1 methylation assays and to evaluate the clinical utility of CDO1 methylation for the management of PCa
9. methylation of the CDO1 gene promoter could be strong prognostic indicator in primary BC without preoperative treatment.
10. CDO1 promoter methylation may not substitute common prognostic makers to predict ccRCC survival, but offers additional, relevant prognostic information, indicating that it might be a novel molecular marker to determine ccRCC prognosis

Submit: New GeneRIF Correction See all GeneRIFs (23)

  The protein CDO1 https://www.ncbi.nlm.nih.gov/protein/NP_001310494.1

LOCUS       NP_001310494             219 aa            linear   PRI 01-JUN-2019
DEFINITION  cysteine dioxygenase type 1 isoform 1 [Homo sapiens].
ACCESSION   NP_001310494
VERSION     NP_001310494.1
DBSOURCE    REFSEQ: accession NM_001323565.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 219)
  AUTHORS   Tanaka Y, Kosaka Y, Waraya M, Yokota K, Harada H, Kaida T, Kikuchi
            M, Minatani N, Nishimiya H, Katoh H, Sengoku N, Watanabe M and
            Yamashita K.
  TITLE     Differential Prognostic Relevance of Promoter DNA Methylation of
            CDO1 and HOPX in Primary Breast Cancer
  JOURNAL   Anticancer Res. 39 (5), 2289-2298 (2019)
   PUBMED   31092420
  REMARK    GeneRIF: In the present study, we compared the 2 potential
            epigenetic prognostic markers of CDO1 hypermethylation and HOPX
            hypermethylation using the same breast cancer samples, and the
            final focus was given on CDO1 hypermethylation
REFERENCE   2  (residues 1 to 219)
  AUTHORS   Yokoi K, Harada H, Yokota K, Ishii S, Tanaka T, Nishizawa N,
            Shimazu M, Kojo K, Miura H, Yamanashi T, Sato T, Nakamura T,
            Watanabe M and Yamashita K.
  TITLE     Epigenetic Status of CDO1 Gene May Reflect Chemosensitivity in
            Colon Cancer with Postoperative Adjuvant Chemotherapy
  JOURNAL   Ann. Surg. Oncol. 26 (2), 406-414 (2019)
   PUBMED   30311169
  REMARK    GeneRIF: High expression of CDO1 gene increased chemoresistance in
            Colon Cancer.
REFERENCE   3  (residues 1 to 219)
  AUTHORS   Nakamoto S, Kumamoto Y, Igarashi K, Fujiyama Y, Nishizawa N, Ei S,
            Tajima H, Kaizu T, Watanabe M and Yamashita K.
  TITLE     Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9
            are prognostic biomarkers in primary extrahepatic
            cholangiocarcinoma
  JOURNAL   PLoS ONE 13 (10), e0205864 (2018)
   PUBMED   30325974
  REMARK    GeneRIF: CDO1 hypermethylation, preoperative serum CA19-9 and
            perineural invasion were independent prognostic factors in primary
            extrahepatic cholangiocarcinoma
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 219)
  AUTHORS   Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii
            S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T,
            Watanabe M and Yamashita K.
  TITLE     Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during
            the adenoma-carcinoma sequence in colorectal cancer
  JOURNAL   PLoS ONE 13 (5), e0194785 (2018)
   PUBMED   29746493
  REMARK    GeneRIF: High CDO1 methylation is associated with colorectal cancer
            progression.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 219)
  AUTHORS   Igarashi K, Yamashita K, Katoh H, Kojima K, Ooizumi Y, Nishizawa N,
            Nishiyama R, Kawamata H, Tajima H, Kaizu T, Kumamoto Y and Watanabe
            M.
  TITLE     Prognostic significance of promoter DNA hypermethylation of the
            cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer
            and gallbladder disease
  JOURNAL   PLoS ONE 12 (11), e0188178 (2017)
   PUBMED   29161283
  REMARK    GeneRIF: Promoter NA methylation of CDO1 was demonstrated for the
            first time to be a cancer-associated methylation in primary
            gallbladder cancer(GBC), and it has the potential to be a
            prognostic biomarker of GBC for high-risk patients with stage II
            GBC.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 219)
  AUTHORS   Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S,
            Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L,
            Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N,
            Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J and Ducar
            M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat. Biotechnol. 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   7  (residues 1 to 219)
  AUTHORS   Qusti S, Parsons RB, Abouglila KD, Waring RH, Williams AC and
            Ramsden DB.
  TITLE     Development of an in vitro model for cysteine dioxygenase
            expression in the brain
  JOURNAL   Cell Biol. Toxicol. 16 (4), 243-255 (2000)
   PUBMED   11101006  The development of an in vitro model for cysteine dioxygenase (CDO) 
expression in the brain would provide a useful model for determining the
 mechanisms for the regulation of CDO expression that does not involve 
the use of animals. Here we demonstrate the screening and 
characterization of a cell line that expresses CDO, the primary 
metabolizing enzyme of cysteine and the regulatory point of sulfate 
production. A panel of four commercially available tumor-derived human 
brain cell lines, each representing one major class of brain cell, were 
screened using western blotting and activity assay for cysteine 
dioxygenase expression. One cell line, TE 671 (human medulloblastoma) 
was found to express both a protein of approximately 70 kDa and CDO 
activity. Nuclease protection assay (NPA) of mRNA isolated from TE 671 
showed the expression of a CDO mRNA. Reverse transcription-polymerase 
chain reaction of this mRNA and sequencing of the cDNA obtained showed 
that this was indeed CDO. Treatment of TE 671 cells with cysteine 
resulted in the upregulation of CDO mRNA, whereas treatment with tumor 
necrosis factor alpha resulted in the downregulation of CDO mRNA, as 
evidenced using NPA. The characterization of an in vitro model for CDO 
expression provides a useful tool for the investigation of this 
important enzyme, which may have an etiological role in the pathogenesis
 of Parkinson's disease.
REFERENCE   8  (residues 1 to 219)
  AUTHORS   Ramsden DB, Kapadi A, Fitch NJ, Farmer MJ, Bennett P and Williams
            AC.
  TITLE     Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5'
            flanking region and intron-exon structure of the gene
  JOURNAL   MP, Mol. Pathol. 50 (5), 269-271 (1997)
   PUBMED   9497919
REFERENCE   9  (residues 1 to 219)
  AUTHORS   Jeremiah S, McCann KP, Williams AC, Ramsden DB, Pilz AJ, Fox MF and
            Povey S.
  TITLE     Chromosomal localisation of genes coding for human and mouse liver
            cytosolic cysteine dioxygenase
  JOURNAL   Ann. Hum. Genet. 60 (1), 29-33 (1996)
   PUBMED   8835096
REFERENCE   10 (residues 1 to 219)
  AUTHORS   McCann KP, Akbari MT, Williams AC and Ramsden DB.
  TITLE     Human cysteine dioxygenase type I: primary structure derived from
            base sequencing of cDNA
  JOURNAL   Biochim. Biophys. Acta 1209 (1), 107-110 (1994)
   PUBMED   7524679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026449.6, DA849625.1, AK130357.1 and BC024241.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.60540.1,
                                           SRR1803613.237389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     Protein         1..219
                     /product="cysteine dioxygenase type 1 isoform 1"
                     /EC_number="1.13.11.20"
                     /note="cysteine dioxygenase, type I"
                     /calculated_mol_wt=24700
     CDS             1..219
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /coded_by="NM_001323565.2:263..922"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:1036"
                     /db_xref="HGNC:HGNC:1795"
                     /db_xref="MIM:603943"
ORIGIN      
        1 meqtevlkpr tladlirilh qlfagdevnv eevqaimeay esdptewamy akfdqysrgr
       61 glqfvvgggs gggwlwytrn lvdqgngkfn lmilcwgegh gssihdhtns hcflkmlqgn
      121 lketlfawpd kksnemvkks ervlrenqca yindsiglhr venishtepa vslhlysppf
      181 dtchafdqrt ghknkvtmtf hskfgirtpn atsgslenn
//

Seuraaksi CSAD- molekyylistä cysteinsulphinic acid , kysteiinisulfiinihappo.